When trying to click on the MDTools options and adjust settings, the error “Object reference not set to an instance of an object” appears. No changes made to settings get saved?

When trying to click on the MDTools options and adjust settings, the error “Object reference not set to an instance of an object” appears. No changes made to settings get saved?

This error can occur if the user profile does not have full permissions to following folder:
C:\ProgramData\VEST\MDTools <version>.
or
Provide full permissions to that folder and then relaunch MDTools.

If issue still exists then reinstall MDTools.